Xtreme Everest 2


Xtreme Everest 2

The Xtreme Everest researchers returned to Everest Base Camp in 2013. Continuing their investigations of human adaptation to hypoxia at high altitude, the key areas of interest for 2013 expedition were:

  • Sherpas
    Sherpas are renowned for being kings of the mountain yet little is known about the differences in their physiology that generate such clear advantages over lowland individuals. Whilst they have undoubtedly inherited genes to aid this from their forefathers, the precise mechanism by which they adapt remains unclear. If we could unravel the secret of Sherpas, we may be able to replicate their superior physiology in critically ill patients.

  • Children
    In 2007 the team studied a small group of children as they ascended to high altitude, taking measurements that had never previously been recorded. The success of this small pilot study led to the creation of a comprehensive study of physiology in children in 2013. A larger group of children followed the path taken by Hilary and Tenzing to a laboratory specially designed for them. Here they underwent rigorous testing to compare their adaptive responses to those of the adults.

  • Twins
    Identical twins share identical genes, yet they exhibit subtle differences. Some of these differences arise from the way in which genes are translated and this emerging field of human biology is called epigenetics. Understanding how our DNA code is modulated throughout life may explain the interactions of nature and nurture. Epigenetics can alter the way we respond to certain circumstances and adaptation to hypoxia may be influenced in this way. We studied identical twins to develop a better understanding of the influence of epigenetics on acclimatisation that could pave the way for artificially influencing it in critically ill patients to promote adaptation and reduce harm.

  • Drug trials
    We were also testing a compound previously studied on our expedition to the Alps in 2010, which aimed to make our lowland travellers 'Sherpa-like.' Initial results from the Alps show that the compound can mimic the blood chemistry of Sherpas and the team were aiming to see if it makes their subjects as fit as Sherpas at high altitude.


The expedition took place from March to May 2013.

Galleries

39 galleries found

Everest Diamond Jubilee

Created : 6th Jun 2013
3 images

Container Loading

Created : 2nd Jun 2013
11 images

Kit arrives in a storm

Created : 23rd May 2013
21 images

EBC Testing KTM

Created : 20th May 2013
9 images

Namche Youth Group

Created : 6th May 2013
26 images

Namche Primary School

Created : 5th May 2013
12 images

EBC Investigators 4

Created : 4th May 2013
4 images

Namche Dental Clinic

Created : 2nd May 2013
11 images

Trek J

Created : 30th Apr 2013
9 images

Sample evacuation from Namche

Created : 30th Apr 2013
12 images

Alan's EBC

Created : 29th Apr 2013
8 images

Trek Champions

Created : 27th Apr 2013
4 images

EBC Investigators 3

Created : 27th Apr 2013
17 images

Moustache madness

Created : 24th Apr 2013
8 images

Namche Clinic

Created : 25th Apr 2013
4 images

EBC Investigators 2

Created : 19th Apr 2013
23 images

Trek I

Created : 15th Apr 2013
8 images

Namche scenery

Created : 15th Apr 2013
8 images

Exercise testing

Created : 13th Apr 2013
7 images

Trek H

Created : 10th Apr 2013
5 images

Trek G

Created : 10th Apr 2013
4 images

Trek Z

Created : 7th Apr 2013
12 images

Trek Y

Created : 5th Apr 2013
10 images

Sherpa Trek C - EBC

Created : 4th Apr 2013
26 images

Trek F

Created : 31st Mar 2013
5 images

Trek E

Created : 26th Mar 2013
23 images

Trek C

Created : 21st Mar 2013
8 images

EBC Investigators

Created : 21st Mar 2013
20 images

Trek D

Created : 21st Mar 2013
5 images

Trek B

Created : 20th Mar 2013
15 images

Trek A

Created : 17th Mar 2013
27 images

Namche Lab

Created : 11th Mar 2013
14 images

XE2 team trekking

Created : 10th Mar 2013
10 images

XE2 in Kathmandu

Created : 10th Mar 2013
9 images

Sherpa testing Kathmandu

Created : 9th Mar 2013
32 images

Arrival in Kathmandu

Created : 5th Mar 2013
6 images

Leaving Heathrow

Created : 5th Mar 2013
6 images

Kathmandu Lab build

Created : 1st Mar 2013
8 images

XE2 Advanced Party

Created : 22nd Feb 2013
14 images